Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability

BACKGROUND: The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforces platelet activation. In addition, FcγRIIA and glycoprotein...

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Publicado en:Res Pract Thromb Haemost
Autores principales: Ahmed, Muhammad Usman, Receveur, Nicolas, Janus‐Bell, Emily, Mouriaux, Clarisse, Gachet, Christian, Jandrot‐Perrus, Martine, Hechler, Béatrice, Gardiner, Elizabeth E., Mangin, Pierre H.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268658/
https://ncbi.nlm.nih.gov/pubmed/34263103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12551
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