Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability

BACKGROUND: The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforces platelet activation. In addition, FcγRIIA and glycoprotein...

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Vydáno v:Res Pract Thromb Haemost
Hlavní autoři: Ahmed, Muhammad Usman, Receveur, Nicolas, Janus‐Bell, Emily, Mouriaux, Clarisse, Gachet, Christian, Jandrot‐Perrus, Martine, Hechler, Béatrice, Gardiner, Elizabeth E., Mangin, Pierre H.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268658/
https://ncbi.nlm.nih.gov/pubmed/34263103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12551
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