Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

MUC16 is overexpressed in ovarian cancer and plays important roles in invasion and metastasis. Previously described monoclonal antibodies against cell surface expressed MUC16 recognize the N-terminal tandemly repeated epitopes present in cancer antigen 125 (CA125). MUC16 is cleaved at a specific loc...

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Pubblicato in:PLoS One
Autori principali: Aithal, Abhijit, Junker, Wade M., Kshirsagar, Prakash, Das, Srustidhar, Kaur, Sukhwinder, Orzechowski, Catherine, Gautam, Shailendra Kumar, Jahan, Rahat, Sheinin, Yuri M., Lakshmanan, Imayavaramban, Ponnusamy, Moorthy P., Batra, Surinder K., Jain, Maneesh
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927449/
https://ncbi.nlm.nih.gov/pubmed/29708979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193907
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