Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

MUC16 is overexpressed in ovarian cancer and plays important roles in invasion and metastasis. Previously described monoclonal antibodies against cell surface expressed MUC16 recognize the N-terminal tandemly repeated epitopes present in cancer antigen 125 (CA125). MUC16 is cleaved at a specific loc...

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發表在:PLoS One
Main Authors: Aithal, Abhijit, Junker, Wade M., Kshirsagar, Prakash, Das, Srustidhar, Kaur, Sukhwinder, Orzechowski, Catherine, Gautam, Shailendra Kumar, Jahan, Rahat, Sheinin, Yuri M., Lakshmanan, Imayavaramban, Ponnusamy, Moorthy P., Batra, Surinder K., Jain, Maneesh
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927449/
https://ncbi.nlm.nih.gov/pubmed/29708979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193907
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