Development and characterization of carboxy-terminus specific monoclonal antibodies for understanding MUC16 cleavage in human ovarian cancer

MUC16 is overexpressed in ovarian cancer and plays important roles in invasion and metastasis. Previously described monoclonal antibodies against cell surface expressed MUC16 recognize the N-terminal tandemly repeated epitopes present in cancer antigen 125 (CA125). MUC16 is cleaved at a specific loc...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Aithal, Abhijit, Junker, Wade M., Kshirsagar, Prakash, Das, Srustidhar, Kaur, Sukhwinder, Orzechowski, Catherine, Gautam, Shailendra Kumar, Jahan, Rahat, Sheinin, Yuri M., Lakshmanan, Imayavaramban, Ponnusamy, Moorthy P., Batra, Surinder K., Jain, Maneesh
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927449/
https://ncbi.nlm.nih.gov/pubmed/29708979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193907
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