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The Novel Anticancer Drug KRN5500 Interacts with, but is Hardly Transported by, Human P‐Glycoprotein

The interaction of the novel anticancer drug KRN5500, a spicamycin derivative, with human Pglycoprotein (P‐gp) was analyzed from the viewpoint of cellular pharmacokinetics, i.e. by means of [(3)H]azidopine photoaffinity labeling, cellular accumulation and transcellular transport experiments. In this...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Takara, Kohji, Tanigawara, Yusuke, Komada, Fusao, Nishiguchi, Kohshi, Sakaeda, Toshiyuki, Okumura, Katsuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926333/
https://ncbi.nlm.nih.gov/pubmed/10761713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2000.tb00938.x
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