UCN‐01 (7‐Hydroxystaurosporine) Enhances 5‐Fluorouracil Cytotoxicity through Down‐regulation of Thymidylate Synthetase Messenger RNA

UCN‐01 (7‐hydroxystaurosporine) is a newly developed cell cycle inhibitor known to have several modes of action, including inhibition of cyclin‐dependent kinase, induction of p21 and suppression of pRb phosphorylation. In order to test a combination therapy of UCN‐01 and 5‐fluorouracil (5‐FU), growt...

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Détails bibliographiques
Publié dans:Jpn J Cancer Res
Auteurs principaux: Abe, Sadanori, Kubota, Tetsuro, Otani, Yoshihide, Furukawa, Toshiharu, Watanabe, Masahiko, Kumai, Koichiro, Kitajima, Masaki
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2000
Sujets:
Rapid Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926291/
https://ncbi.nlm.nih.gov/pubmed/11092986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2000.tb00904.x
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