UCN‐01 (7‐Hydoxystaurosporine) Inhibits in vivo Growth of Human Cancer Cells through Selective Perturbation of G1 Phase Checkpoint Machinery

Mechanisms underlying tumor sensitivity to the antitumor agent UCN‐01 (7‐hydroxystaurosporine) were examined in the nude mouse model using three human tumor xenografts, two pancreatic cancers (PAN‐3‐JCK and CRL 1420) and a breast cancer (MX‐1). UCN‐01 antitumor activity was evaluated in terms of rel...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Abe, Sadanori, Kubota, Tetsuro, Otani, Yoshihide, Furukawa, Toshiharu, Watanabe, Masahiko, Kumai, Koichiro, Akiyama, Tadakazu, Akinaga, Shiro, Kitajima, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926745/
https://ncbi.nlm.nih.gov/pubmed/11376563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2001.tb01127.x
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