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UCN‐01 (7‐Hydroxystaurosporine) Enhances 5‐Fluorouracil Cytotoxicity through Down‐regulation of Thymidylate Synthetase Messenger RNA
UCN‐01 (7‐hydroxystaurosporine) is a newly developed cell cycle inhibitor known to have several modes of action, including inhibition of cyclin‐dependent kinase, induction of p21 and suppression of pRb phosphorylation. In order to test a combination therapy of UCN‐01 and 5‐fluorouracil (5‐FU), growt...
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| Pubblicato in: | Jpn J Cancer Res |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Publishing Ltd
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5926291/ https://ncbi.nlm.nih.gov/pubmed/11092986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2000.tb00904.x |
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