A phase 1 study of AMG 900, an orally administered pan-aurora kinase inhibitor, in adult patients with acute myeloid leukemia

Aurora kinases are involved in the pathophysiology of several cancers including acute myeloid leukemia (AML). In this phase 1 study, we investigated the safety and efficacy of AMG 900, an orally administered, highly potent, selective, small-molecule inhibitor of both Aurora kinase A and B, in patien...

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Detalhes bibliográficos
Publicado no:Am J Hematol
Main Authors: Kantarjian, Hagop M., Schuster, Michael W., Jain, Nitin, Advani, Anjali, Jabbour, Elias, Gamelin, Erick, Rasmussen, Erik, Juan, Gloria, Anderson, Abraham, Chow, Vincent F., Friberg, Gregory, Vogl, Florian D., Sekeres, Mikkael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925751/
https://ncbi.nlm.nih.gov/pubmed/28370201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.24736
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