Dual targeting of aurora kinases with AMG 900 exhibits potent preclinical activity against acute myeloid leukemia with distinct post-mitotic outcomes

Aurora kinase A and B have essential and non-overlapping roles in mitosis, with elevated expression in a subset of human cancers, including acute myeloid leukemia (AML). In this study, pan-aurora kinase inhibitor (AKI) AMG 900 distinguishes itself as an anti-leukemic agent that is more uniformly pot...

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Bibliografiska uppgifter
I publikationen:Mol Cancer Ther
Huvudupphovsmän: Payton, Marc, Cheung, Hung-Kam, Ninniri, Maria Stefania S., Marinaccio, Christian, Wayne, William C., Hanestad, Kelly, Crispino, John D., Juan, Gloria, Coxon, Angela
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6279493/
https://ncbi.nlm.nih.gov/pubmed/30266802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0186
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