Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer

Histone deacetylase inhibitors (HDACIs) are being tested in clinical trials for the treatment of solid tumors. While most studies have focused on the reexpression of silenced tumor suppressor genes, a number of genes/pathways are downregulated by HDACIs. This provides opportunities for combination t...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Paller, Channing J, Wissing, Michel D, Mendonca, Janet, Sharma, Anup, Kim, Eugene, Kim, Hea-Soo, Kortenhorst, Madeleine S Q, Gerber, Stephanie, Rosen, Marc, Shaikh, Faraz, Zahurak, Marianna L, Rudek, Michelle A, Hammers, Hans, Rudin, Charles M, Carducci, Michael A, Kachhap, Sushant K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Clinical Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302682/
https://ncbi.nlm.nih.gov/pubmed/24989836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.289
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