Characterization of Hit Compounds Identified from High-Throughput Screening for their Effect on Blood-Brain Barrier Integrity and Amyloid-β Clearance: In vitro and in vivo Studies

In Alzheimer’s disease (AD) the blood-brain barrier (BBB) is compromised, thus therapeutic targeting of the BBB to enhance its integrity and function could be a unique approach to treat, slow or hold the progression of AD. Recently, we have developed an in vitro high-throughput screening assay to sc...

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Pubblicato in:Neuroscience
Autori principali: Elfakhri, Khaled H, Duong, Quoc-Viet, Langley, Courtney, Depaula, Ashley, Mousa, Youssef M, Lebeouf, Trista, Cain, Courtney, Kaddoumi, Amal
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924725/
https://ncbi.nlm.nih.gov/pubmed/29596966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2018.03.028
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