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A pathway for mitotic chromosome formation
Mitotic chromosomes fold as compact arrays of chromatin loops. To identify the pathway of mitotic chromosome formation, we combined imaging and Hi-C of synchronous DT40 cell cultures with polymer simulations. We show that in prophase, the interphase organization is rapidly lost in a condensin-depend...
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| 發表在: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5924687/ https://ncbi.nlm.nih.gov/pubmed/29348367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao6135 |
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