Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization

The molecular mechanisms underlying folding of mammalian chromosomes remain poorly understood. The transcription factor CTCF is a candidate regulator of chromosomal structure. Using the auxin-inducible degron system in mouse embryonic stem cells, we show that CTCF is absolutely and dose-dependently...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Nora, Elphège P., Goloborodko, Anton, Valton, Anne-Laure, Gibcus, Johan H., Uebersohn, Alec, Abdennur, Nezar, Dekker, Job, Mirny, Leonid A., Bruneau, Benoit G.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538188/
https://ncbi.nlm.nih.gov/pubmed/28525758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.05.004
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