Molecular basis of CTCF binding polarity in genome folding

Current models propose that boundaries of mammalian topologically associating domains (TADs) arise from the ability of the CTCF protein to stop extrusion of chromatin loops by cohesin. While the orientation of CTCF motifs determines which pairs of CTCF sites preferentially stabilize loops, the molec...

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Publicado en:Nat Commun
Main Authors: Nora, Elphège P., Caccianini, Laura, Fudenberg, Geoffrey, So, Kevin, Kameswaran, Vasumathi, Nagle, Abigail, Uebersohn, Alec, Hajj, Bassam, Saux, Agnès Le, Coulon, Antoine, Mirny, Leonid A., Pollard, Katherine S., Dahan, Maxime, Bruneau, Benoit G.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645679/
https://ncbi.nlm.nih.gov/pubmed/33154377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19283-x
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