Deuterated Polyunsaturated Fatty Acids Reduce Brain Lipid Peroxidation and Hippocampal Amyloid β-Peptide Levels, Without Discernable Behavioral Effects in an APP/PS1 Mutant Transgenic Mouse Model of Alzheimer's Disease

Alzheimer's disease (AD) involves progressive deposition of amyloid β-peptide (Aβ), synapse loss and neuronal death, which occur in brain regions critical for learning and memory. Considerable evidence suggests that lipid peroxidation contributes to synaptic dysfunction and neuronal degeneratio...

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Pubblicato in:Neurobiol Aging
Autori principali: Raefsky, Sophia M., Furman, Ran, Milne, Ginger, Pollock, Erik, Axelsen, Paul, Mattson, Mark P., Shchepinov, Mikhail S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924637/
https://ncbi.nlm.nih.gov/pubmed/29579687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.02.024
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