Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein

Lipid peroxidation is a key to a portfolio of neurodegenerative diseases and plays a central role in α-synuclein (α-syn) toxicity, mitochondrial dysfunction and neuronal death, all key processes in the pathogenesis of Parkinson’s disease (PD). Polyunsaturated fatty acids (PUFAs) are important consti...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol Commun
Auteurs principaux: Beal, M. Flint, Chiluwal, Jayandra, Calingasan, Noel Y., Milne, Ginger L., Shchepinov, Mikhail S., Tapias, Victor
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7731572/
https://ncbi.nlm.nih.gov/pubmed/33308320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-01090-6
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