Inactivation of the Pseudomonas-Derived Cephalosporinase-3 (PDC-3) by Relebactam

Pseudomonas aeruginosa is a prevalent and life-threatening Gram-negative pathogen. Pseudomonas-derived cephlosporinase (PDC) is the major inducible cephalosporinase in P. aeruginosa. In this investigation, we show that relebactam, a diazabicyclooctane β-lactamase inhibitor, potently inactivates PDC-...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Barnes, Melissa D., Bethel, Christopher R., Alsop, Jim, Becka, Scott A., Rutter, Joseph D., Papp-Wallace, Krisztina M., Bonomo, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923161/
https://ncbi.nlm.nih.gov/pubmed/29530851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02406-17
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