Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa

Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. In response to this significant clinical threat, ce...

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Dades bibliogràfiques
Publicat a:mBio
Autors principals: Barnes, Melissa D., Taracila, Magdalena A., Rutter, Joseph D., Bethel, Christopher R., Galdadas, Ioannis, Hujer, Andrea M., Caselli, Emilia, Prati, Fabio, Dekker, John P., Papp-Wallace, Krisztina M., Haider, Shozeb, Bonomo, Robert A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6299481/
https://ncbi.nlm.nih.gov/pubmed/30538183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02085-18
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