p16(INK4) Expression Is Associated with the Increased Sensitivity of Human Non‐small Cell Lung Cancer Cells to DNA Topoisomerase I Inhibitors

Inactivation of p16(INK4), an inhibitor of cyclin‐dependent kinases 4 (CDK4) and 6 (CDK6), may be essential for ontogenesis in non‐small cell lung cancer (NSCLC). We examined the sensitivity of two clones of P16(INK4)‐transfected NSCLC cell line with homozygous deletion of p16(INK4), A549/pl6‐l and...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Fukuoka, Kazuya, Adachi, Jun‐ichi, Nishio, Kazuto, Arioka, Hitoshi, Kurokawa, Hirokazu, Fukumoto, Hisao, Ishida, Tomoyuki, Nomoto, Taisuke, Yokote, Hideyuki, Tomonari, Akira, Narita, Nobuhiro, Yokota, Jun, Saijo, Nagahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921277/
https://ncbi.nlm.nih.gov/pubmed/9414664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00322.x
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