Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling

mTORC1 is a signal integrator and master regulator of cellular anabolic processes linked to cell growth and survival. Here we demonstrate that mTORC1 promotes lipid biogenesis via SRPK2, a key regulator of RNA-binding SR proteins. mTORC1-activated S6K1 phosphorylates SRPK2 at Ser494, which primes Se...

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Udgivet i:Cell
Main Authors: Lee, Gina, Zheng, Yuxiang, Cho, Sungyun, Jang, Cholsoon, England, Christina, Dempsey, Jamie M., Yu, Yonghao, Liu, Xiaolei, He, Long, Cavaliere, Paola M., Chavez, Andre, Zhang, Erik, Isik, Meltem, Couvillon, Anthony, Dephoure, Noah E., Blackwell, T. Keith, Yu, Jane J., Rabinowitz, Joshua D., Cantley, Lewis C., Blenis, John
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920692/
https://ncbi.nlm.nih.gov/pubmed/29153836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.037
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