Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling

mTORC1 is a signal integrator and master regulator of cellular anabolic processes linked to cell growth and survival. Here we demonstrate that mTORC1 promotes lipid biogenesis via SRPK2, a key regulator of RNA-binding SR proteins. mTORC1-activated S6K1 phosphorylates SRPK2 at Ser494, which primes Se...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell
Main Authors: Lee, Gina, Zheng, Yuxiang, Cho, Sungyun, Jang, Cholsoon, England, Christina, Dempsey, Jamie M., Yu, Yonghao, Liu, Xiaolei, He, Long, Cavaliere, Paola M., Chavez, Andre, Zhang, Erik, Isik, Meltem, Couvillon, Anthony, Dephoure, Noah E., Blackwell, T. Keith, Yu, Jane J., Rabinowitz, Joshua D., Cantley, Lewis C., Blenis, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920692/
https://ncbi.nlm.nih.gov/pubmed/29153836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.037
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados