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RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors
CRISPR-Cas9 transcriptional repressors have emerged as robust tools for disrupting gene regulation in vitro but have not yet been adapted for systemic delivery in adult animal models. Here we describe a Staphylococcus aureus Cas9-based repressor (dSaCas9(KRAB)) compatible with adeno-associated viral...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5920046/ https://ncbi.nlm.nih.gov/pubmed/29700298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04048-4 |
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