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Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation

PURPOSE: Inhalation therapy is popular to treat lower respiratory tract infections. Azithromycin is effective against some bacteria that cause respiratory tract infections; but it has poor water solubility that may limit its efficacy when administrated as inhalation therapy. In this study, dry powde...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Pharm Res
Hauptverfasser: Mangal, Sharad, Nie, Haichen, Xu, Rongkun, Guo, Rui, Cavallaro, Alex, Zemlyanov, Dmitry, Zhou, Qi (Tony)
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918295/
https://ncbi.nlm.nih.gov/pubmed/29374368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2334-9
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