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Reversal of Methotrexate Cytotoxicity to Human Bone Marrow Cells and Leukemic K562 Cells by Leucovorin: Methotrexate Polyglutamates Formation as a Possible Important Factor
Methotrexate (MIX) is metabolized intracellularly to MTX‐polyglutamates (MTX‐PGs), which markedly inhibit several folate‐dependent enzymes. Polyglutamation defect, therefore, is one of the important factors in drug resistance. In this study, reversal of MTX cytotoxicity by l‐leucovorin (l‐LV) was in...
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| Publicado en: | Jpn J Cancer Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
1990
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5917995/ https://ncbi.nlm.nih.gov/pubmed/1702414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1990.tb02529.x |
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