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Reversal of Methotrexate Cytotoxicity to Human Bone Marrow Cells and Leukemic K562 Cells by Leucovorin: Methotrexate Polyglutamates Formation as a Possible Important Factor

Methotrexate (MIX) is metabolized intracellularly to MTX‐polyglutamates (MTX‐PGs), which markedly inhibit several folate‐dependent enzymes. Polyglutamation defect, therefore, is one of the important factors in drug resistance. In this study, reversal of MTX cytotoxicity by l‐leucovorin (l‐LV) was in...

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Detalles Bibliográficos
Publicado en:Jpn J Cancer Res
Main Authors: Koizumi, Shoichi, Ueno, Yoshiki, Ohno, Ichiro, Ichihara, Tsuyoshi, Tamaru, Yoichi, Matsukawa, Harumi
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 1990
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917995/
https://ncbi.nlm.nih.gov/pubmed/1702414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1990.tb02529.x
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