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Impairment of Methotrexate (MTX)‐Polyglutamate Formation of MTX‐resistant K562 Cell Lines
We examined the mechanism of methotrexate (MTX) resistance in five K562 cell subclones resistant to MTX. Based on a clonogenic assay, the IC(50)s of these MTX‐resistant clones were 10 to 40μMMTX, indicating 2,000 to 5,000‐fold resistance as compared to that of the parent cell line. The doubling time...
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| Publicado no: | Jpn J Cancer Res |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
1988
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5917644/ https://ncbi.nlm.nih.gov/pubmed/2465288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1988.tb01549.x |
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