PTEN deficiency promotes pathological vascular remodeling of human coronary arteries

Phosphatase and tensin homolog (PTEN) is an essential regulator of the differentiated vascular smooth muscle cell (SMC) phenotype. Our goal was to establish that PTEN loss promotes SMC dedifferentiation and pathological vascular remodeling in human atherosclerotic coronary arteries and nonatheroscle...

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Vydáno v:JCI Insight
Hlavní autoři: Moulton, Karen S., Li, Marcella, Strand, Keith, Burgett, Shawna, McClatchey, Penn, Tucker, Rebecca, Furgeson, Seth B., Lu, Sizhao, Kirkpatrick, Bruce, Cleveland, Joseph C., Nemenoff, Raphael A., Ambardekar, Amrut V., Weiser-Evans, Mary C.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916252/
https://ncbi.nlm.nih.gov/pubmed/29467331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97228
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