A carregar...
Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity
A series of hydroxamic acids linked by different lengths to a chiral imidazo-ketopiperazine scaffold were synthesized. The compounds with linker lengths of 6 and 7 carbon atoms were the most potent in histone deacetylase (HDAC) inhibition, and were specific submicromolar inhibitors of the HDAC1, HDA...
Na minha lista:
| Publicado no: | Philos Trans R Soc Lond B Biol Sci |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2018
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915728/ https://ncbi.nlm.nih.gov/pubmed/29685969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0364 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|