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Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition
We designed and synthesized carbamates of the clinically-approved HDAC (histone deacetylase) inhibitor vorinostat (suberoylanilide hydroxamic acid, SAHA) in order to validate our previously-proposed hypothesis that these carbamates might serve as prodrugs for hydroxamic acid containing HDAC inhibito...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6017415/ https://ncbi.nlm.nih.gov/pubmed/29393896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23020321 |
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