Загрузка...
Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity
A series of hydroxamic acids linked by different lengths to a chiral imidazo-ketopiperazine scaffold were synthesized. The compounds with linker lengths of 6 and 7 carbon atoms were the most potent in histone deacetylase (HDAC) inhibition, and were specific submicromolar inhibitors of the HDAC1, HDA...
Сохранить в:
| Опубликовано в: : | Philos Trans R Soc Lond B Biol Sci |
|---|---|
| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Royal Society
2018
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915728/ https://ncbi.nlm.nih.gov/pubmed/29685969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0364 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|