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Rational design of selective allosteric inhibitors of PHDGH and serine synthesis with in vivo activity
Metabolic reprogramming in cancer cells facilitates growth and proliferation. Increased activity of the serine biosynthetic pathway through the enzyme phosphoglycerate dehydrogenase (PHGDH) contributes to tumorigenesis. With a small substrate and a weak binding cofactor (NAD(+)), inhibitor developme...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5915676/ https://ncbi.nlm.nih.gov/pubmed/28042046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.11.013 |
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