The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia

Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein, spongiform changes in the brain, and brain inflammation as a result of the wide-spread activation of microglia. Autophagy is a highly conserved catabolic process for the clearance of cytoplas...

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Bibliographic Details
Published in:Front Aging Neurosci
Main Authors: Lai, Mengyu, Yao, Hao, Shah, Syed Zahid Ali, Wu, Wei, Wang, Di, Zhao, Ying, Wang, Lu, Zhou, Xiangmei, Zhao, Deming, Yang, Lifeng
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915529/
https://ncbi.nlm.nih.gov/pubmed/29720937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00116
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