Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway

Transcription factors play a significant role during the symptomatic onset and progression of prion diseases. We previously showed the immunomodulatory and nuclear factor of activated T cells’ (NFAT) suppressive effects of an immunosuppressant, FK506, in the symptomatic stage and an antibiotic, mino...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Shah, Syed Zahid Ali, Zhao, Deming, Taglialatela, Giulio, Hussain, Tariq, Dong, Haodi, Sabir, Naveed, Mangi, Mazhar Hussain, Wu, Wei, Lai, Mengyu, Zhang, Xixi, Duan, Yuhan, Wang, Lu, Zhou, Xiangmei, Yang, Lifeng
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429086/
https://ncbi.nlm.nih.gov/pubmed/30845718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20051144
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