Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway

Transcription factors play a significant role during the symptomatic onset and progression of prion diseases. We previously showed the immunomodulatory and nuclear factor of activated T cells’ (NFAT) suppressive effects of an immunosuppressant, FK506, in the symptomatic stage and an antibiotic, mino...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Shah, Syed Zahid Ali, Zhao, Deming, Taglialatela, Giulio, Hussain, Tariq, Dong, Haodi, Sabir, Naveed, Mangi, Mazhar Hussain, Wu, Wei, Lai, Mengyu, Zhang, Xixi, Duan, Yuhan, Wang, Lu, Zhou, Xiangmei, Yang, Lifeng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429086/
https://ncbi.nlm.nih.gov/pubmed/30845718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20051144
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