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p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases
Prion diseases are a group of fatal and debilitating neurodegenerative diseases affecting humans and animal species. The conversion of a non-pathogenic normal cellular protein (PrP(c)) into an abnormal infectious, protease-resistant, pathogenic form prion protein scrapie (PrP(Sc)), is considered the...
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| Publicado no: | Front Mol Neurosci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6180192/ https://ncbi.nlm.nih.gov/pubmed/30337853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00310 |
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