p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

Prion diseases are a group of fatal and debilitating neurodegenerative diseases affecting humans and animal species. The conversion of a non-pathogenic normal cellular protein (PrP(c)) into an abnormal infectious, protease-resistant, pathogenic form prion protein scrapie (PrP(Sc)), is considered the...

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Detalles Bibliográficos
Publicado en:Front Mol Neurosci
Autores principales: Shah, Syed Zahid Ali, Zhao, Deming, Hussain, Tariq, Sabir, Naveed, Mangi, Mazhar Hussain, Yang, Lifeng
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180192/
https://ncbi.nlm.nih.gov/pubmed/30337853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00310
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