Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model

Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii. In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log(10) per thigh were observed for all exposures for which area under the curve (AUC)/MIC ra...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Kang, Anthony D., Smith, Kenneth P., Berg, Anders H., Truelson, Katherine A., Eliopoulos, George M., McCoy, Christopher, Kirby, James E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2018
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913965/
https://ncbi.nlm.nih.gov/pubmed/29339396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02585-17
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