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Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic Reticulum Associated Degradation
Misfolded proteins in the endoplasmic reticulum (ER) are destroyed by ER-associated degradation (ERAD). Although the retrotranslocation of misfolded proteins from the ER has been reconstituted, how a polypeptide is initially selected for ERAD remains poorly defined. To address this question while co...
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| Publicat a: | Mol Cell |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5912696/ https://ncbi.nlm.nih.gov/pubmed/29677492 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.016 |
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