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Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic Reticulum Associated Degradation

Misfolded proteins in the endoplasmic reticulum (ER) are destroyed by ER-associated degradation (ERAD). Although the retrotranslocation of misfolded proteins from the ER has been reconstituted, how a polypeptide is initially selected for ERAD remains poorly defined. To address this question while co...

詳細記述

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書誌詳細
出版年:Mol Cell
主要な著者: Preston, G. Michael, Guerriero, Christopher J., Metzger, Meredith B., Michaelis, Susan, Brodsky, Jeffrey L.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912696/
https://ncbi.nlm.nih.gov/pubmed/29677492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.03.016
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