Hsp104 facilitates the endoplasmic‐reticulum–associated degradation of disease‐associated and aggregation‐prone substrates

Misfolded proteins in the endoplasmic reticulum (ER) are selected for ER‐associated degradation (ERAD). More than 60 disease‐associated proteins are substrates for the ERAD pathway due to the presence of missense or nonsense mutations. In yeast, the Hsp104 molecular chaperone disaggregates detergent...

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Detaylı Bibliyografya
Yayımlandı:Protein Sci
Asıl Yazarlar: Doonan, Lynley M., Guerriero, Christopher J., Preston, G. Michael, Buck, Teresa M., Khazanov, Netaly, Fisher, Edward A., Senderowitz, Hanoch, Brodsky, Jeffrey L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley & Sons, Inc. 2019
Konular:
Full‐Length Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566541/
https://ncbi.nlm.nih.gov/pubmed/31050848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3636
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