Hsp104 facilitates the endoplasmic‐reticulum–associated degradation of disease‐associated and aggregation‐prone substrates

Misfolded proteins in the endoplasmic reticulum (ER) are selected for ER‐associated degradation (ERAD). More than 60 disease‐associated proteins are substrates for the ERAD pathway due to the presence of missense or nonsense mutations. In yeast, the Hsp104 molecular chaperone disaggregates detergent...

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Publicado en:Protein Sci
Main Authors: Doonan, Lynley M., Guerriero, Christopher J., Preston, G. Michael, Buck, Teresa M., Khazanov, Netaly, Fisher, Edward A., Senderowitz, Hanoch, Brodsky, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Inc. 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566541/
https://ncbi.nlm.nih.gov/pubmed/31050848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3636
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