Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication

In this study, we investigated the effects of the dual phosphatidylinositol 3-kinase/mechanistic target of rapamycin (PI3K/MTOR) inhibitor dactolisib (NVP-BEZ235), the PI3K/MTOR/bromodomain-containing protein 4 (BRD4) inhibitor SF2523, and the bromodomain and extra terminal domain inhibitor JQ1 on t...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Campbell, Grant R., Bruckman, Rachel S., Herns, Shayna D., Joshi, Shweta, Durden, Donald L., Spector, Stephen A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912471/
https://ncbi.nlm.nih.gov/pubmed/29475942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002353
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