Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

MYC is a major cancer driver but is documented to be a difficult therapeutic target itself. Here, we report on the biological activity, the structural basis, and therapeutic effects of the family of multitargeted compounds that simultaneously disrupt functions of two critical MYC-mediating factors t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Andrews, Forest H., Singh, Alok R., Joshi, Shweta, Smith, Cassandra A., Morales, Guillermo A., Garlich, Joseph R., Durden, Donald L., Kutateladze, Tatiana G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320964/
https://ncbi.nlm.nih.gov/pubmed/28137841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613091114
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