Distinct functions for the membrane-proximal ectodomain region (MPER) of HIV-1 gp41 in cell-free and cell–cell viral transmission and cell–cell fusion

HIV-1 is spread by cell-free virions and by cell–cell viral transfer. We asked whether the structure and function of a broad neutralizing antibody (bNAb) epitope, the membrane-proximal ectodomain region (MPER) of the viral gp41 transmembrane glycoprotein, differ in cell-free and cell–cell-transmitte...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Narasimhulu, Vani G. S., Bellamy-McIntyre, Anna K., Laumaea, Annamarie E., Lay, Chan-Sien, Harrison, David N., King, Hannah A. D., Drummer, Heidi E., Poumbourios, Pantelis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912456/
https://ncbi.nlm.nih.gov/pubmed/29496992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000537
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