Role for the Terminal Clasp of HIV-1 gp41 Glycoprotein in the Initiation of Membrane Fusion

The binding by HIV-1 gp120 to CD4 and a chemokine receptor activates the membrane fusion glycoprotein, gp41. The fusion function of gp41 involves the refolding of its core into a 6-helix bundle, which apposes the lipophilic termini (the fusion peptide and transmembrane domain) and the associated cel...

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Bibliografiske detaljer
Main Authors: Lay, Chan-Sien, Ludlow, Louise E., Stapleton, David, Bellamy-McIntyre, Anna K., Ramsland, Paul A., Drummer, Heidi E., Poumbourios, Pantelis
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308845/
https://ncbi.nlm.nih.gov/pubmed/21976663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.299826
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