Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41

BACKGROUND: The disulfide-bonded region (DSR) of HIV-1 gp41 mediates association with gp120 and plays a role in transmission of receptor-induced conformational changes in gp120 to gp41 that activate membrane fusion function. In this study, forced viral evolution of a DSR mutant that sheds gp120 was...

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Detalhes bibliográficos
Main Authors: Khasawneh, Ashraf I, Laumaea, Annemarie, Harrison, David N, Bellamy-McIntyre, Anna K, Drummer, Heidi E, Poumbourios, Pantelis
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643854/
https://ncbi.nlm.nih.gov/pubmed/23618462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-44
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