A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity

Bispecific antibodies have become important formats for therapeutic discovery. They allow for potential synergy by simultaneously engaging two separate targets and enable new functions that are not possible to achieve by using a combination of two monospecific antibodies. Antagonistic antibodies dom...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shi, Sally Yu, Lu, Ya-Wen, Liu, Zhi, Stevens, Jennitte, Murawsky, Christopher M., Wilson, Vicki, Hu, Zhonghua, Richards, William G., Michaels, Mark Leo, Zhang, Jun, Yan, Wei, Li, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912448/
https://ncbi.nlm.nih.gov/pubmed/29483191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001752
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