A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity

Bispecific antibodies have become important formats for therapeutic discovery. They allow for potential synergy by simultaneously engaging two separate targets and enable new functions that are not possible to achieve by using a combination of two monospecific antibodies. Antagonistic antibodies dom...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Shi, Sally Yu, Lu, Ya-Wen, Liu, Zhi, Stevens, Jennitte, Murawsky, Christopher M., Wilson, Vicki, Hu, Zhonghua, Richards, William G., Michaels, Mark Leo, Zhang, Jun, Yan, Wei, Li, Yang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912448/
https://ncbi.nlm.nih.gov/pubmed/29483191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001752
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