A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity

Bispecific antibodies have become important formats for therapeutic discovery. They allow for potential synergy by simultaneously engaging two separate targets and enable new functions that are not possible to achieve by using a combination of two monospecific antibodies. Antagonistic antibodies dom...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Shi, Sally Yu, Lu, Ya-Wen, Liu, Zhi, Stevens, Jennitte, Murawsky, Christopher M., Wilson, Vicki, Hu, Zhonghua, Richards, William G., Michaels, Mark Leo, Zhang, Jun, Yan, Wei, Li, Yang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2018
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912448/
https://ncbi.nlm.nih.gov/pubmed/29483191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001752
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