Cyclic GMP-AMP Synthase cGAS is the cytosolic sensor of Plasmodium falciparum genomic DNA and activates type I interferons in malaria

Innate immune receptors have a key role in the sensing of malaria and initiating immune responses. As a consequence of infection, systemic inflammation emerges and is directly related to signs and symptoms during acute disease. We have previously reported that Plasmodial DNA is the primary driver of...

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Publicado en:J Immunol
Autores principales: Gallego-Marin, Carolina, Schrum, Jacob E., Andrade, Warrison A., Shaffer, Scott A., Giraldo, Lina F., Lasso, Alvaro M., Kurt-Jones, Evelyn A., Fitzgerald, Kate A., Golenbock, Douglas T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912257/
https://ncbi.nlm.nih.gov/pubmed/29212905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701048
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