Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox

All known orthopoxviruses, including ectromelia virus (ECTV), contain a gene in the E3L family. The protein product of this gene, E3, is a double-stranded RNA-binding protein. It can impact host range and is used by orthopoxviruses to combat cellular defense pathways, such as PKR and RNase L. In thi...

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Publicado en:Virology
Autores principales: Frey, Tiffany R., Forsyth, Katherine S., Sheehan, Maura M., DeHaven, Brian C., Pevarnik, Julia G., Hand, Erin S., Pizzorno, Marie C., Eisenlohr, Laurence C., Hersperger, Adam R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911240/
https://ncbi.nlm.nih.gov/pubmed/29602068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.03.016
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