Foot-and-mouth disease virus type O specific mutations determine RNA-dependent RNA polymerase fidelity and virus attenuation

Previous studies have shown that the FMDV Asia1/YS/CHA/05 high-fidelity mutagen-resistant variants are attenuated (Zeng et al., 2014). Here, we introduced the same single or multiple-amino-acid substitutions responsible for increased 3D(pol) fidelity of type Asia1 FMDV into the type O FMDV O/YS/CHA/...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Li, Chen, Wang, Haiwei, Yuan, Tiangang, Woodman, Andrew, Yang, Decheng, Zhou, Guohui, Cameron, Craig E., Yu, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911202/
https://ncbi.nlm.nih.gov/pubmed/29455065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.01.030
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